Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis.

Circulation - 8 Jun 1999

Wittrup H H, Tybjaerg-Hansen A, Nordestgaard B G

Abstract excerpt

BACKGROUND: We assessed in meta-analyses the effect of the Gly188Glu, Asp9Asn, Asn291Ser, and Ser447Ter substitutions in lipoprotein lipase in the heterozygous state on lipid metabolism and risk of ischemic heart disease (same order used below). METHODS AND RESULTS: In 29 separate studies, 20 903 white subjects were screened for >/=1 of these substitutions; each meta-analysis included only some of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-I
Share to Apolipoproteins B
Share to Cholesterol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cholesterol, HDL

Share to Heparin

Share to Lipoprotein Lipase

Share to Lipoproteins

Share to Myocardial Ischemia

Source

Identifiers

PMID: 10359734
DOI: 10.1161/01.cir.99.22.2901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis.PMID 10359734Read ↗

Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease.Semantic proximity Read ↗

Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study.Semantic proximity Read ↗

A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease.Semantic proximity Read ↗

Functional variants in the lipoprotein lipase gene and risk cardiovascular disease.Semantic proximity Read ↗

[Frequent mutation doubles the risk of ischemic heart disease in women].Semantic proximity Read ↗

Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis.Semantic proximity Read ↗

Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease.Semantic proximity Read ↗

The heterozygous N291S mutation in the lipoprotein lipase gene impairs whole-body insulin sensitivity and affects a distinct set of plasma metabolites in humans.Semantic proximity Read ↗

Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: the Copenhagen City Heart Study.Semantic proximity Read ↗

Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies.Semantic proximity Read ↗

A common mutation in lipoprotein lipase confers a 2-fold increase in risk of ischemic cerebrovascular disease in women but not in men.Semantic proximity Read ↗

Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.