Article
Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation.
BMC cancer - 2 Dec 2002
Kratz John E, Stearns Duncan, Huso David L, Slunt Hilda H, Price Donald L, Borchelt David R, Eberhart Charles G
Abstract excerpt
BACKGROUND: Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor formation, we created transgenic mice expressing either wild-type or activated beta-catenin in the brain. METHODS: Wild-type and mutant human beta-catenin transgenes were expressed under the...
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