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Article

Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells.

Science (New York, N.Y.) - 13 Feb 2004

Lee Hye-Youn, Kléber Maurice, Hari Lisette, Brault Véronique, Suter Ueli, Taketo Makoto M, Kemler Rolf, Sommer Lukas

Abstract excerpt

Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/beta-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained beta-cate...

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Source

Identifiers

PMID: 14716020
DOI: 10.1126/science.1091611

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14716020-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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