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Article

Autoimmune disease. A problem of defective apoptosis.

Arthritis and rheumatism - 1 Oct 1994

Mountz J D, Wu J, Cheng J, Zhou T

Abstract excerpt

Human autoimmune diseases share the common feature of an imbalance between the production and destruction of various cell types including lymphocytes (SLE), synovial cells (RA), and fibroblasts (scleroderma). Patients with SLE have increased levels of soluble Fas that inhibit proper apoptosis of lymphocytes. In animal models of autoimmune diseases, mutations of genes involved in apoptosis including Fas, Fas...

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Identifiers

PMID: 7524507
DOI: 10.1002/art.1780371002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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