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Article

Autoimmune disease. A problem of defective apoptosis.

Arthritis and rheumatism - 1 Oct 1994

Mountz J D, Wu J, Cheng J, Zhou T

Abstract excerpt

Human autoimmune diseases share the common feature of an imbalance between the production and destruction of various cell types including lymphocytes (SLE), synovial cells (RA), and fibroblasts (scleroderma). Patients with SLE have increased levels of soluble Fas that inhibit proper apoptosis of lymphocytes. In animal models of autoimmune diseases, mutations of genes involved in apoptosis including Fas, Fas...

Topics

Antigens, Surface
Apoptosis
Autoimmune Diseases
Autoimmunity
Cell Division
Genes, myc
Genes, p53
Humans
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
fas Receptor

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Identifiers

PMID: 7524507
DOI: 10.1002/art.1780371002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7524507-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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