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Article

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene.

Arthritis and rheumatism - 1 Jun 2003

Szalai Alexander J, Weaver Casey T, McCrory Mark A, van Ginkel Frederik W, Reiman Rachael M, Kearney John F, Marion Tony N, Volanakis John E

Abstract excerpt

OBJECTIVE: Human C-reactive protein (CRP) binds apoptotic cells and alters blood clearance of injected chromatin in mice. To test whether CRP participates in the pathogenesis of systemic lupus erythematosus (SLE), we examined disease development in lupus-prone (NZB x NZW)F(1) (NZB/NZW) mice expre...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12794828
DOI: 10.1002/art.11026

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12794828-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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