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Article

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene.

Arthritis and rheumatism - 1 Jun 2003

Szalai Alexander J, Weaver Casey T, McCrory Mark A, van Ginkel Frederik W, Reiman Rachael M, Kearney John F, Marion Tony N, Volanakis John E

Abstract excerpt

OBJECTIVE: Human C-reactive protein (CRP) binds apoptotic cells and alters blood clearance of injected chromatin in mice. To test whether CRP participates in the pathogenesis of systemic lupus erythematosus (SLE), we examined disease development in lupus-prone (NZB x NZW)F(1) (NZB/NZW) mice expressing a human CRP transgene (hCRPtg/BW). METHODS: Mortality was monitored, proteinuria was determined by dipstick, and...

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PMID: 12794828
DOI: 10.1002/art.11026

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CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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