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Article

A novel mouse model expressing human forms for complement receptors CR1 and CR2.

BMC genetics - 9 Sept 2020

Jackson Harriet M, Foley Kate E, O'Rourke Rita, Stearns Timothy M, Fathalla Dina, Morgan B Paul, Howell Gareth R

Abstract excerpt

BACKGROUND: The complement cascade is increasingly implicated in development of a variety of diseases with strong immune contributions such as Alzheimer's disease and Systemic Lupus Erythematosus. Mouse models have been used to determine function of central components of the complement cascade such as C1q and C3. However, species differences in their gene structures mean that mice do not adequately replicate...

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Identifiers

PMID: 32907542
DOI: 10.1186/s12863-020-00893-9
PMCID: PMC7487969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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