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CYTOPROTECTION OF PANCREATIC ISLETS BEFORE AND SOON AFTER TRANSPLANTATION BY GENE TRANSFER OF THE ANTI-APOPTOTIC Bcl-2 GENE1

1 Apr 2001

Abstract excerpt

Isolated pancreatic islet transplantation is a promising alternative to conventional insulin-dependent diabetes treatment but is not yet a practical clinical therapy. In the first few days after pancreatic islet transplantation, substantial donor pancreatic islet dysfunction and apoptosis commonly occur. Islet apoptosis has been documented after extracellular matrix disruption and exposure to proinflammatory...

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PMID: 11374395
DOI: 10.1097/00007890-200104270-00001

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