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A Simple High Efficiency Intra-Islet Transduction Protocol Using Lentiviral Vectors

22 Jul 2015

Abstract excerpt

Successful normalization of blood glucose in patients transplanted with pancreatic islets isolated from cadaveric donors established the proof-of-concept that Type 1 Diabetes Mellitus is a curable disease. Nonetheless, major caveats to the widespread use of this cell therapy approach have been the shortage of islets combined with the low viability and functional rates subsequent to transplantation. Gene therapy...

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PMID: 26122098
DOI: 10.2174/1566523215666150630121557

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