Article
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.
Transplantation - 27 Apr 2002
Mathews Clayton E, Langley Stephen H, Leiter Edward H
Abstract excerpt
BACKGROUND: Islet transplantation studies with diabetic rodents frequently use treatment with diabetogens such as alloxan or streptozotocin to render hosts hyperglycemic. These chemicals produce unwanted toxic side effects, which complicate interpretations of damage produced by hyperglycemia versus direct toxin-induced damage. A mouse that spontaneously developed insulin-sensitive diabetes without beta-cell...
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