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Article

Improving Islet Engraftment by Gene Therapy

1 Jan 2011

Abstract excerpt

Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon islet infusion, hypoxia induced by the low oxygenated milieu, and poor-revascularization-mediated lack of nutrients,...

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Identifiers

PMID: 22132301
DOI: 10.1155/2011/594851

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