Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cells.

Nutrition and cancer - 1 Jan 2003

Forest Virginie, Clement Monique, Pierre Fabrice, Meflah Khaled, Menanteau Jean

Abstract excerpt

Loss of function of the Apc gene product is an early and frequent event in colorectal carcinogenesis. Altered migration of intestinal epithelial cells has been described in vivo in the Min mouse Apc+/Min model. Using cell lines established from this model we show in vitro that Apc+/Min cells are less motile than Apc+/+ cells and exhibit a disordered actin cytoskeletal network. This would increase the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Butyrates

Share to Cytoskeleton

Share to Epithelial Cells

Share to Genes, APC

Share to Genes, Tumor Suppressor

Share to Microscopy, Fluorescence

Source

Identifiers

PMID: 12791508
DOI: 10.1207/S15327914NC4501_10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cells.PMID 12791508Read ↗

Adenomatous polyposis coli truncation alters cytoskeletal structure and microtubule stability in early intestinal tumorigenesis.Semantic proximity Read ↗

<i>Apc<sup>Min</sup></i><sup>/+</sup> mouse model of colon cancer: Gene expression profiling in tumorsSemantic proximity Read ↗

Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice.Semantic proximity Read ↗

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS.Semantic proximity Read ↗

Regulation of human colonic cell line proliferation and phenotype by sodium butyrate.Semantic proximity Read ↗

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.Semantic proximity Read ↗

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.Semantic proximity Read ↗

Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.Semantic proximity Read ↗

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.Semantic proximity Read ↗

Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc.Semantic proximity Read ↗

Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway.Semantic proximity Read ↗

Intestinal immune responses in wild-type and Apcmin/+ mouse, a model for colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.