Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS.

DNA and cell biology - 1 Jan 2005

Ramsay Robert G, Ciznadija Daniel, Sicurella Catherine, Reyes Nancy, Mitchelhill Ken, Darcy Phillip K, D'Abaco Giovanna, Mantamadiotis Theo

Abstract excerpt

Blocked differentiation is a hallmark of cancer cells and the restoration of differentiation programs in vivo is an actively pursued clinical aim. Understanding the key regulators of cyto-differentiation may focus therapies on molecules that reactivate this process. c-myb expression declines rapidly when human colon cancer epithelial cells are induced to differentiate with the physiologically relevant short-chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli Protein
Share to Alkaline Phosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Butyrates

Share to Cytosol

Share to Intestinal Mucosa

Share to Proto-Oncogene Proteins c-myb

Share to Wnt Proteins

Source

Identifiers

PMID: 15684716
DOI: 10.1089/dna.2005.24.21

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS.PMID 15684716Read ↗

The Intestinal Epithelial Cell Differentiation Marker Intestinal Alkaline Phosphatase (ALPi) Is Selectively Induced by Histone Deacetylase Inhibitors (HDACi) in Colon Cancer Cells in a Kruppel-like Factor 5 (KLF5)-dependent MannerSemantic proximity Read ↗

Short chain fatty acids differentially modulate cellular phenotype and c-myc protein levels in primary human nonmalignant and malignant colonocytes.Semantic proximity Read ↗

The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation.Semantic proximity Read ↗

Butyrate restores motile function and actin cytoskeletal network integrity in apc mutated mouse colon epithelial cells.Semantic proximity Read ↗

Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity.Semantic proximity Read ↗

Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.Semantic proximity Read ↗

Regulation of VDR Expression in <i>Apc</i> -Mutant Mice, Human Colon Cancers and AdenomasSemantic proximity Read ↗

Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon CancerSemantic proximity Read ↗

HDAC3 overexpression and colon cancer cell proliferation and differentiationSemantic proximity Read ↗

Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.Semantic proximity Read ↗

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling.Semantic proximity Read ↗

Myc deletion rescues Apc deficiency in the small intestine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.