Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of drug-specific T cells in lamotrigine hypersensitivity.

The Journal of allergy and clinical immunology - 1 Jun 2003

Naisbitt Dean J, Farrell John, Wong Gavin, Depta Jan P H, Dodd Charlotte C, Hopkins Josephine E, Gibney Claire A, Chadwick David W, Pichler Werner J, Pirmohamed Munir, Park B Kevin

Abstract excerpt

BACKGROUND: Lamotrigine is associated with hypersensitivity reactions, which are most commonly characterized by skin rash. An immune etiology has been postulated, though the nature of this is unclear. OBJECTIVES: The aim of this study was to characterize the role of T cells in lamotrigine hypersensitivity. METHODS: A lymphocyte transformation test was performed on 4 hypersensitive patients. Lymphocytes from 3 of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity Tests, Immunologic

Share to Drug Hypersensitivity

Share to HLA-DQ Antigens

Share to Lamotrigine

Share to Models, Immunological

Share to Triazines

Source

Identifiers

PMID: 12789244
DOI: 10.1067/mai.2003.1507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of drug-specific T cells in lamotrigine hypersensitivity.PMID 12789244Read ↗

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones.Semantic proximity Read ↗

Lamotrigine-induced hypersensitivity syndrome in a Han Chinese patient with the HLA-B 5801 genotype.Semantic proximity Read ↗

T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.Semantic proximity Read ↗

Phenotypic diversity in delayed drug hypersensitivity: an immunologic explanation.Semantic proximity Read ↗

Association between HLA-DRB1*0405, -DQB1*0401 and -DQA1*0303 alleles and lamotrigine-induced cutaneous adverse drug reactions. A pilot case-control study from Japan.Semantic proximity Read ↗

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.Semantic proximity Read ↗

Anticonvulsant hypersensitivity syndrome: a review.Semantic proximity Read ↗

Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitizationSemantic proximity Read ↗

Role of T cells in drug allergies.Semantic proximity Read ↗

Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS.Semantic proximity Read ↗

Characterisation of the phenotype and function of drug-responsive T-cells in patients with drug-induced liver injurySemantic proximity Read ↗

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.