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Article

Analysis of differential gene expression of PBMC for the in vitro detection of drug sensitization

11 Jan 2025

Abstract excerpt

BACKGROUND: The detection of drug-specific activation of T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, the LTT presents with a varying sensitivity and specificity. The aim of our study was to analyse the genome wide gene expression of PBMC to identify drug allergy-specific gene regulation patterns. Additionally, gene expression...

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PMID: 39800649
DOI: 10.1016/j.alit.2024.11.006

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