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Article

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994

Hursting S D, Perkins S N, Phang J M

Abstract excerpt

Transgenic mice with both alleles of the p53 tumor suppressor gene (frequently mutated in human tumors) knocked out by gene targeting provide a potentially useful tumorigenesis model because these mice rapidly develop spontaneous tumors. To determine whether tumorigenesis in p53-knockout mice is...

Topics

Alleles
Animals
Energy Intake
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mutagenesis
Neoplasms, Experimental
Time Factors
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8041741
DOI: 10.1073/pnas.91.15.7036
PMCID: PMC44333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8041741-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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