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Article

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994

Hursting S D, Perkins S N, Phang J M

Abstract excerpt

Transgenic mice with both alleles of the p53 tumor suppressor gene (frequently mutated in human tumors) knocked out by gene targeting provide a potentially useful tumorigenesis model because these mice rapidly develop spontaneous tumors. To determine whether tumorigenesis in p53-knockout mice is sensitive to experimental manipulation, tumor development in response to calorie restriction (CR; a potent inhibitor of...

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Identifiers

PMID: 8041741
DOI: 10.1073/pnas.91.15.7036
PMCID: PMC44333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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