Article
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
The Journal of biological chemistry - 7 Jul 2000
de Rooij J, Rehmann H, van Triest M, Cool R H, Wittinghofer A, Bos J L
Abstract excerpt
Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) are closely related guanine nucleotide exchange factors (GEFs) for the small GTPase Rap1, which are directly regulated by cAMP. Here we show that both GEFs efficiently activate Rap2 as well. A third member of the family, Repac (GFR), which lacks the cAMP dependent regulatory sequences, is a constitutive activator of both Rap1 and Rap2. In contrast to Epac1, Epac2 contains...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.