Article
Furin-like enzyme dependency in KRAS-mutant colorectal cancer as a target for personalized treatment strategies.
Biochimica et biophysica acta. Reviews on cancer - 1 Sept 2026
Siegfried Geraldine, Liu Yiyang, He Zongcheng, Evrard Serge, Badiola Iker, Pernot Simon, Creemers John W M, Khatib Abdel-Majid
Abstract excerpt
Increasing efforts have focused on identifying vulnerabilities within the signaling networks of KRAS that sustain its oncogenic activity. Recently, Furin-like enzymes or proprotein convertase, proteases responsible for the activation of various signaling molecules, have emerged as key regulators. Furin, modulate KRAS-related signaling by processing growth factors, cytokines, and receptor tyrosine kinases (RTKs)....
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