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Article

The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.

Oncogene - 1 Apr 2020

He Zongsheng, Thorrez Lieven, Siegfried Geraldine, Meulemans Sandra, Evrard Serge, Tejpar Sabine, Khatib Abdel-Majid, Creemers John W M

Abstract excerpt

Mutations in KRAS and/or BRAF that activate the ERK kinase are frequently found in colorectal cancer (CRC) and drive resistance to targeted therapies. Therefore, the identification of therapeutic targets that affect multiple signaling pathways simultaneously is crucial for improving the treatment of patients with KRAS or BRAF mutations. The proprotein convertase furin activates several oncogenic protein...

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PMID: 32139876
DOI: 10.1038/s41388-020-1238-z

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