Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma.

CNS neuroscience & therapeutics - 1 Mar 2017

Wei Jian-Wei, Cai Jin-Quan, Fang Chuan, Tan Yan-Li, Huang Kai, Yang Chao, Chen Qun, Jiang Chuan-Lu, Kang Chun-Sheng

Abstract excerpt

BACKGROUND AND AIMS: EGFRvIII is the most prevalent glioblastoma mutation, occurring in more than 25% of glioblastomas. EGFRvIII cells release microvesicles that contain proteins, miRNAs, and mRNAs that enhance the growth and survival of surrounding tumor cells. However, little is known about the maturation process and regulatory mechanisms of secreted vesicles in EGFRvIII cells. METHODS: Signal peptide peptidase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Glioblastoma

Share to Mice, Nude

Share to RNA, Small Interfering

Share to Transforming Growth Factor alpha

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 28198167
DOI: 10.1111/cns.12672
PMCID: PMC6492646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal Peptide Peptidase, Encoded by HM13, Contributes to Tumor Progression by Affecting EGFRvIII Secretion Profiles in Glioblastoma.PMID 28198167Read ↗

Comparative proteomic analysis of three major extracellular classes secreted from human adenocarcinoma and metastatic colorectal cancer cells: exosomes, microparticles and shed midbody remnantsSemantic proximity Read ↗

Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells.Semantic proximity Read ↗

Targeting miR-9 in Glioma Stem Cell-Derived Extracellular Vesicles: A Novel Diagnostic and Therapeutic BiomarkerSemantic proximity Read ↗

Cell-specific crosstalk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zoneSemantic proximity Read ↗

Computational Screening of Secretory Proteins With Brain-Specific Expression in Glioblastoma MultiformeSemantic proximity Read ↗

Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive diseaseSemantic proximity Read ↗

Peptidylarginine Deiminases—Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?Semantic proximity Read ↗

A Journey on Extracellular Vesicles for Matrix Metalloproteinases: A Mechanistic PerspectiveSemantic proximity Read ↗

Extracellular Matrix Proteome Remodeling in Human Glioblastoma and MedulloblastomaSemantic proximity Read ↗

Targeting miR-9 in Glioma Stem Cell-Derived Extracellular Vesicles: A Novel Diagnostic and Therapeutic BiomarkerSemantic proximity Read ↗

Cell-specific cross-talk proteomics reveals cathepsin B signaling as a driver of glioblastoma malignancy near the subventricular zoneSemantic proximity Read ↗

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.