Article
Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias.
British journal of haematology - 1 Jun 2003
Care Rory S, Valk Peter J M, Goodeve Anne C, Abu-Duhier Faisel M, Geertsma-Kleinekoort Wendy M C, Wilson Giu A, Gari Mamdooh A, Peake Ian R, Löwenberg Bob, Reilly John T
Abstract excerpt
DNA from 110 adult de novo acute myeloid leukaemia (AML) patients exhibiting either inv(16) (n = 63) or t(8;21) (n = 47) was screened for mutations in the c-KIT (exon 8 and Asp816) and FLT3 (ITD and Asp835) genes. c-KIT exon 8 mutations were found in 15/63 (23.8%) inv(16) patients and 1/47 (2.1%) t(8;21) patients. c-KIT Asp816 mutations were present in 5/63 (7.9%) inv(16) AML and 5/47 (10.6%) t(8;21) AML. FLT3...
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