Article
Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.
Blood - 25 Mar 2010
Pollard Jessica A, Alonzo Todd A, Gerbing Robert B, Ho Phoenix A, Zeng Rong, Ravindranath Yaddanapudi, Dahl Gary, Lacayo Norman J, Becton David, Chang Myron, Weinstein Howard J, Hirsch Betsy, Raimondi Susana C, Heerema Nyla A, Woods William G, Lange Beverly J, Hurwitz Craig, Arceci Robert J, Radich Jerald P, Bernstein Irwin D, Heinrich Michael C, Meshinchi Soheil
Abstract excerpt
KIT receptor tyrosine kinase mutations are implicated as a prognostic factor in adults with core binding factor (CBF) acute myeloid leukemia (AML). However, their prevalence and prognostic significance in pediatric CBF AML is not well established. We performed KIT mutational analysis (exon 8 and exon 17) on diagnostic specimens from 203 pediatric patients with CBF AML enrolled on 4 pediatric AML protocols. KIT...
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