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HumanSP-Cgene sequences that confer lung epithelium-specific expression in transgenic mice

1 May 2000

Abstract excerpt

We used transgenic mice to identify cis-active regions of the human pulmonary surfactant protein C (SP-C) gene that impart tissue- and cell-specific expression in vivo in the lung. Approximately 3.7 kb of genomic SP-C DNA upstream of the transcription start site was sufficient to direct chloramphenicol acetyltransferase (CAT) reporter gene expression specifically in bronchiolar and alveolar epithelial cells of...

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PMID: 10781423
DOI: 10.1152/ajplung.2000.278.5.l933

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