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Article

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.

The Journal of cell biology - 8 May 2006

Wang Weigang, Mouneimne Ghassan, Sidani Mazen, Wyckoff Jeffrey, Chen Xiaoming, Makris Anastasia, Goswami Sumanta, Bresnick Anne R, Condeelis John S

Abstract excerpt

Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine-threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin polymerization and depolymerization during cell migration....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16651380
DOI: 10.1083/jcb.200510115
PMCID: PMC2063840

Genes

LIMK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors.PMID 16651380Read ↗

LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer.Semantic proximity Read ↗

A role for LIM kinase in cancer invasion.Semantic proximity Read ↗

Characterization of LIMA1 and its emerging roles and potential therapeutic prospects in cancersSemantic proximity Read ↗

LIM kinases: cofilin and beyondSemantic proximity Read ↗

O-GlcNAcylation of cofilin promotes breast cancer cell invasion.Semantic proximity Read ↗

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1Semantic proximity Read ↗

LIM kinase 1 interacts with myosin-9 and alpha-actinin-4 and promotes colorectal cancer progression.Semantic proximity Read ↗

LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodelingSemantic proximity Read ↗

ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells.Semantic proximity Read ↗

Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2.Semantic proximity Read ↗

Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.Semantic proximity Read ↗

Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.Semantic proximity Read ↗

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