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Article

ROCK signaling mediates the adoption of different modes of migration and invasion in human mammary epithelial tumor cells.

Experimental cell research - 15 Nov 2006

Torka Robert, Thuma Florian, Herzog Volker, Kirfel Gregor

Abstract excerpt

For the invasive migration of tumor cells, at least two mechanisms are currently discussed: (1) the mesenchymal mode depending on extracellular proteolysis and (2) the proteolysis-independent amoeboid mode depending on the activity of the Rho kinase ROCK. The ability of tumor cells to switch between different modes of motility has been shown to limit the efficiency of agents aimed to reduce invasion. Here we show...

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Identifiers

PMID: 17010335
DOI: 10.1016/j.yexcr.2006.08.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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