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Article

ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.

The Journal of biological chemistry - 8 Aug 2003

Dong Jing-fei, Moake Joel L, Bernardo Aubrey, Fujikawa Kazuo, Ball Chalmette, Nolasco Leticia, López José A, Cruz Miguel A

Abstract excerpt

Thrombotic thrombocytopenic purpura is caused by congenital or acquired deficiency of ADAMTS-13, a metalloprotease that cleaves the endothelium-derived ultra-large multimers of von Willebrand factor (ULVWF). The proteolysis converts hyper-reactive and thrombogenic ULVWF into smaller and less adhesive plasma forms. Activity of ADAMTS-13 is usually measured in a static system under non-physiological conditions that...

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Identifiers

PMID: 12775718
DOI: 10.1074/jbc.M301385200

Genes

VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.PMID 12775718Read ↗

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