Article

Interaction between the metalloprotease ADAMTS-13 and the proteins of the alternative pathway of the complement system

2017-01-01

Abstract excerpt

Von Willebrand factor (VWF), a multimeric protein that has a central role in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement, a...

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Literature Corpus work: 68a500cc-7b0b-500f-8500-356cd5c89020
DOI: 10.21954/ou.ro.0000c453

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