Article
Insights into von Willebrand factor proteolysis: clinical implications.
British journal of haematology - 1 Jun 2006
Bowen D J, Collins P W
Abstract excerpt
The proteolysis of von Willebrand factor (VWF) by the recently discovered metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin repeats), is a normal processing step in VWF biochemistry. Emerging data indicate that this step may be influenced by a variety of factors, some of which favour increased proteolysis and some of which compromise proteolysis. The former may predispose to...
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