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Article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.

Molecular biology of the cell - 1 Oct 2011

Vascotto Carlo, Bisetto Elena, Li Mengxia, Zeef Leo A H, D'Ambrosio Chiara, Domenis Rossana, Comelli Marina, Delneri Daniela, Scaloni Andrea, Altieri Fabio, Mavelli Irene, Quadrifoglio Franco, Kelley Mark R, Tell Gianluca

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1) protects cells from oxidative stress via the base excision repair pathway and as a redox transcriptional coactivator. It is required for tumor progression/metastasis, and its up-regulation is associated with cancer resistance. Loss of APE1 expression causes cell growth arrest, mitochondrial impairment, apoptosis, and alterations of the intracellular redox...

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Identifiers

PMID: 21865600
DOI: 10.1091/mbc.E11-05-0391
PMCID: PMC3192867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.PMID 21865600Read ↗

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