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Article

Comparison of the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha on estimated and measured beta cell indices.

European journal of endocrinology - 1 Jun 2003

Chiu Ken C, Chuang Lee-Ming, Chu Audrey, Yoon Carol, Wang Max

Abstract excerpt

OBJECTIVE: We investigated the impact of the I27L polymorphism of the hepatocyte nuclear factor-1alpha gene on measured and estimated beta cell indices. We also examined the conservation of this amino acid among different species. DESIGN AND METHODS: Estimated first and second phase insulin responses (1stPH(S) and 2ndPH(S)) were estimated from oral glucose tolerance tests in 78 glucose tolerant subjects. Among...

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PMID: 12773136
DOI: 10.1530/eje.0.1480641

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