Article
The A98V single nucleotide polymorphism (SNP) in hepatic nuclear factor 1 alpha (HNF-1alpha) is associated with insulin sensitivity and beta-cell function.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Sept 2008
Bergmann A, Li J, Selisko T, Reimann M, Fischer S, Grässler J, Schulze J, Bornstein S R, Schwarz P E H
Abstract excerpt
OBJECTIVE: Mutations in the hepatic nuclear factor-1-alpha ( HNF-1alpha) gene is considered as a candidate for the aetiology of type 2 diabetes. The aims of the study was to determine whether two single nucleotide polymorphisms (SNPs) ile27-to-leu and ala98-to-val in the HNF-1alpha gene associate with diabetes, insulin sensitivity as well as beta-cell function. RESEARCH DESIGN AND METHODS: 1 479 subjects of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.