Article
The Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene contributes to the interindividual variation in serum C-peptide response during an oral glucose tolerance test: evidence from studies of 231 glucose-tolerant first degree relatives of type 2 diabetic probands.
The Journal of clinical endocrinology and metabolism - 1 Dec 1998
Urhammer S A, Hansen T, Ekstrøm C T, Eiberg H, Pedersen O
Abstract excerpt
The third form of maturity-onset diabetes of the young is caused by mutations in the hepatocyte nuclear factor-1alpha gene. Recently, we demonstrated an association between a prevalent polymorphism at codon 98, Ala/Val98, of this gene and a 20% decreased insulin release during an oral glucose tol...
Topics
- Adult
- Amino Acid Sequence
- C-Peptide
- DNA-Binding Proteins
- Diabetes Mellitus
- Female
- Genetic Variation
- Glucose
- Glucose Tolerance Test
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans