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Article

Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.

The Journal of clinical endocrinology and metabolism - 1 Jun 1997

Urhammer S A, Hansen T, Jensen L B, Clausen J O, Hansen L, Chui K C, Pedersen O

Abstract excerpt

Because a frequently occurring nucleotide substitution at position -258 in the liver glucokinase promoter has been reported to be associated with impaired promoter activity, we have examined in Danish Caucasians whether this variant is associated with alterations in glucose tolerance and/or the insulin sensitivity index (Si). Among 246 Danish Caucasian patients with noninsulin-dependent diabetes mellitus, the...

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Identifiers

PMID: 9177383
DOI: 10.1210/jcem.82.6.3977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Studies of the impact of a liver glucokinase promoter variant on glucose tolerance and insulin sensitivity index.PMID 9177383Read ↗

Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.Semantic proximity Read ↗

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns.Semantic proximity Read ↗

The g/a nucleotide variant at position -30 in the beta-cell-specific glucokinase gene promoter has no impact on the beta-cell function in Danish Caucasians.Semantic proximity Read ↗

The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients.Semantic proximity Read ↗

The beta cell glucokinase promoter variant is an unlikely risk factor for diabetes mellitus. Diabetes Incidence Study in Sweden (DISS).Semantic proximity Read ↗

The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.Semantic proximity Read ↗

In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity.Semantic proximity Read ↗

Homozygosity for a common polymorphism in the islet-specific promoter of the glucokinase gene is associated with a reduced early insulin response to oral glucose in pregnant women.Semantic proximity Read ↗

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Glucokinase gene in gestational diabetes mellitus: population association study and molecular scanning.Semantic proximity Read ↗

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance.Semantic proximity Read ↗

Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.Semantic proximity Read ↗

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