Article
New insulin sensitivity adjusted beta cell indices: validation according to a genetic study.
Pancreas - 1 Aug 2003
Chiu Ken C, Martinez Dorothy S, Lee Nancy P, Saad Mohammed F
Abstract excerpt
PURPOSE: The role of hepatocyte nuclear factor-1alpha (HNF1alpha) in the maturity-onset diabetes of the young 3 (MODY3) is well established. A common polymorphism, I27L that is not linked to MODY3, has been demonstrated to affect beta cell function. To facilitate the identification of subjects with a low beta cell reserve, we developed beta cell indices and validated according to a genetic study. METHODS: Insulin...
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