Article
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism - 1 Nov 1998
Urhammer S A, Møller A M, Nyholm B, Ekstrøm C T, Eiberg H, Clausen J O, Hansen T, Pedersen O, Schmitz O
Abstract excerpt
The objective of the present study was to investigate whether the frequent amino acid polymorphisms, Ile/Leu27 and Ser/Asn487, of the hepatocyte nuclear factor-1alpha gene were associated with alterations in glucose-induced serum C-peptide and serum insulin responses among glucose-tolerant first-...
Topics
- Adult
- Amino Acid Substitution
- Asparagine
- C-Peptide
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Female
- Genetic Variation
- Glucose Tolerance Test
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta