Article
The effect of two frequent amino acid variants of the hepatocyte nuclear factor-1alpha gene on estimates of the pancreatic beta-cell function in Caucasian glucose-tolerant first-degree relatives of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism - 1 Nov 1998
Urhammer S A, Møller A M, Nyholm B, Ekstrøm C T, Eiberg H, Clausen J O, Hansen T, Pedersen O, Schmitz O
Abstract excerpt
The objective of the present study was to investigate whether the frequent amino acid polymorphisms, Ile/Leu27 and Ser/Asn487, of the hepatocyte nuclear factor-1alpha gene were associated with alterations in glucose-induced serum C-peptide and serum insulin responses among glucose-tolerant first-degree relatives of type 2 diabetic patients. The study comprised 2 independent Danish cohorts. Among 74 unrelated type...
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