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Article

HNF-1alpha G574S is a functional variant with decreased transactivation activity.

Diabetic medicine : a journal of the British Diabetic Association - 1 Dec 2006

Navalón-García K, Mendoza-Alcantar L, Díaz-Vargas M E, Martínez-Godínez M A, Reyna-Garfias H, Aguilar-Salinas C A, Riba L, Canizales-Quinteros S, Villarreal-Molina T, González-Chávez A, Argueta-Villamar V, Tusié-Luna M T, Miliar-García A

Abstract excerpt

AIM: To assess the functional consequence of the hepatocyte nuclear factor 1alpha gene (HNF-1alpha) G574S variant previously proposed as a diabetes susceptibility allele, in a group of Mexican Type 2 diabetic patients with end-stage renal disease (ESRD). METHODS: The transcriptional activity of the HNF-1alpha G574S recombinant protein on the human insulin promoter was assessed by transfection assays in RINm5f and...

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Identifiers

PMID: 17116178
DOI: 10.1111/j.1464-5491.2006.02008.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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