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Article

A STAT-regulated, stress-induced signalling pathway in Dictyostelium.

Journal of cell science - 15 Jul 2003

Araki Tsuyoshi, Tsujioka Masatsune, Abe Tomoaki, Fukuzawa Masashi, Meima Marcel, Schaap Pauline, Morio Takahiro, Urushihara Hideko, Katoh Mariko, Maeda Mineko, Tanaka Yoshimasa, Takeuchi Ikuo, Williams Jeffrey G

Abstract excerpt

The Dictyostelium stalk cell inducer differentiation-inducing factor (DIF) directs tyrosine phosphorylation and nuclear accumulation of the STAT (signal transducer and activator of transcription) protein Dd-STATc. We show that hyperosmotic stress, heat shock and oxidative stress also activate Dd-STATc. Hyperosmotic stress is known to elevate intracellular cGMP and cAMP levels, and the membrane-permeant analogue...

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PMID: 12771188
DOI: 10.1242/jcs.00501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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