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Article

Osmotic stress response in Dictyostelium is mediated by cAMP.

The EMBO journal - 1 Nov 2000

Ott A, Oehme F, Keller H, Schuster S C

Abstract excerpt

DokA, a homolog of bacterial hybrid histidine kinases, is essential for hyperosmotic stress resistance in Dictyostelium: We show that a transient intracellular cAMP signal, dependent on the presence of DokA, is generated in response to an osmotic shock. This variation of cAMP levels contributes to survival under hypertonic conditions. In contrast to the low cAMP levels observed in dokA(-) strains, overexpression...

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Identifiers

PMID: 11060029
DOI: 10.1093/emboj/19.21.5782
PMCID: PMC305785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Osmotic stress response in Dictyostelium is mediated by cAMP.PMID 11060029Read ↗

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A STAT-regulated, stress-induced signalling pathway in Dictyostelium.Semantic proximity Read ↗

An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium.Semantic proximity Read ↗

A conserved signalling pathway for amoebozoan encystation that was co-opted for multicellular development.Semantic proximity Read ↗

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