Article
Osmotic stress response in Dictyostelium is mediated by cAMP.
The EMBO journal - 1 Nov 2000
Ott A, Oehme F, Keller H, Schuster S C
Abstract excerpt
DokA, a homolog of bacterial hybrid histidine kinases, is essential for hyperosmotic stress resistance in Dictyostelium: We show that a transient intracellular cAMP signal, dependent on the presence of DokA, is generated in response to an osmotic shock. This variation of cAMP levels contributes t...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- 8-Bromo Cyclic Adenosine Monophosphate
- Animals
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- DNA-Binding Proteins
- Dictyostelium
- Gene Expression
- Osmotic Pressure
- Phenotype
- Protein Kinases
- Protein Structure, Tertiary