Article
Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas.
Molecular carcinogenesis - 1 Jun 2003
Patrikis Maria I, Bryan Emma J, Thomas Nicola A, Rice Greg E, Quinn Michael A, Baker Mark S, Campbell Ian G
Abstract excerpt
Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular pathology. We used single-stranded conformational polymorphism/heteroduplex analysis to analyze 42 unselected uterine leiomyomas for somatic mutations in all coding exons of the gene encoding CCAAT displacement protein (CDP), as well as exons 5-8 of TP53 and codons 1-36 and 38-80 of KRAS. No somatic...
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