Article
Chromosome imbalances and alterations in the p53 gene in uterine myomas from the same family members: familial leiomyomatosis in Turkey.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Hakverdi Sibel, Demirhan Osman, Tunc Erdal, Inandiklioglu Nihal, Uslu Inayet Nur, Gungoren Arif, Erdem Duygu, Hakverdi Ali Ulvi
Abstract excerpt
Uterine leiomyomas (UL) are extremely common neoplasms in women of reproductive age, and are associated with a variety of characteristic choromosomal aberrations (CAs). The p53 gene has been reported to play a crucial role in suppressing the growth of a variety of cancer cells. Therefore, the present study investigated the effects of CAs and the p53 gene on ULs. We performed cytogenetic analysis by G-banding in...
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