Article
Low frequency of somatic mutations in uterine sarcomas: a molecular analysis and review of the literature.
Mutation research - 1 Apr 2010
Murray S, Linardou H, Mountzios G, Manoloukos M, Markaki S, Eleutherakis-Papaiakovou E, Dimopoulos M A, Papadimitriou C A
Abstract excerpt
OBJECTIVE: The rarity of uterine sarcomas along with their pathological and molecular heterogeneities render their study particularly challenging. We evaluated a panel of somatic mutations principally centering on the tyrosine kinase gene family and their downstream signaling cascades in an attempt to identify potential candidate markers that may assist in diagnostic or therapeutic decisions in these tumors....
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