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Article

Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2003

Haberstock-Debic Helena, Wein Marc, Barrot Michel, Colago Eric E O, Rahman Zia, Neve Rachael L, Pickel Virginia M, Nestler Eric J, von Zastrow Mark, Svingos Adena L

Abstract excerpt

Morphine stimulates the internalization of mu-opioid receptors (MORs) in transfected cell models to a lesser degree than opioid peptides and other analgesic drugs, such as methadone, and previous studies have reported that morphine does not produce a detectable redistribution of MORs in neural tissue after either acute or chronic administration. Nevertheless, morphine produces profound physiological effects,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12764121
PMCID: PMC6741100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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