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Article

Cellular and molecular abnormalities in severe congenital neutropenia predisposing to leukemia.

Experimental hematology - 1 May 2003

Aprikyan Andrew A G, Kutyavin Tatyana, Stein Steven, Aprikian Pavel, Rodger Elin, Liles W Conrad, Boxer Laurence A, Dale David C

Abstract excerpt

Severe congenital neutropenia (SCN) is a rare hematological disease characterized by a selective decrease in the level of circulating neutrophils in peripheral blood, maturation arrest at the promyelocyte stage of differentiation in the bone marrow, recurrent severe infections, and evolution to acute myelogenous leukemia (AML). Cellular and molecular studies of 12 SCN patients, including 5 patients that evolved...

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Identifiers

PMID: 12763135
DOI: 10.1016/s0301-472x(03)00048-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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