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Article

Severe congenital neutropenia: genetics and pathogenesis.

Transactions of the American Clinical and Climatological Association - 1 Jan 2006

Boxer Laurence A

Abstract excerpt

Severe congenital neutropenia (SCN) is a rare hematological disease characterized by a selective decrease in circulating neutrophils, bone marrow maturation arrest at the promyelocyte stage, and occurrence of infections. Studies of SCN patients revealed impaired proliferative characteristics and accelerated apoptosis of bone marrow progenitor cells. Sequencing analysis indicated a heterozygous deletion or...

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Identifiers

PMID: 18528462
PMCID: PMC1500938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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