Article
A comparison of the defective granulopoiesis in childhood cyclic neutropenia and in severe congenital neutropenia.
Haematologica - 1 Aug 2005
Sera Yasuhiko, Kawaguchi Hiroshi, Nakamura Kazuhiro, Sato Takashi, Habara Masakazu, Okada Satoshi, Ishikawa Nobutsune, Kojima Seiji, Katoh Osamu, Kobayashi Masao
Abstract excerpt
BACKGROUND AND OBJECTIVES: Cyclic neutropenia (CyN) in childhood and severe congenital neutropenia (SCN) are congenital disorders that cause chronic neutropenia. Mutations in the neutrophil elastase gene, ELA2, have been reported in patients with CyN and in those with SCN. We examined granulopoietic defects in CyN patients with those in SCN patients. DESIGN AND METHODS: Three patients with CyN and four with SCN...
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