Article
Severe congenital neutropenia: inheritance and pathophysiology.
Current opinion in hematology - 1 Jan 2007
Skokowa Julia, Germeshausen Manuela, Zeidler Cornelia, Welte Karl
Abstract excerpt
PURPOSE OF REVIEW: Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10/l. In this review we summarize our current knowledge on inheritance and pathophysiolgy of congenital neutropenia. RECENT FINDINGS: There are two major subtypes of congenital...
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