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Article

Mutant elastase in pathogenesis of cyclic and severe congenital neutropenia.

Journal of pediatric hematology/oncology - 1 Dec 2002

Aprikyan Andrew A G, Liles W Conrad, Boxer Laurence A, Dale David C

Abstract excerpt

Severe neutropenia is characterized by maturation arrest of myeloid cells at the promyelocyte stage of hematopoiesis. We reported that accelerated apoptosis of bone marrow myeloid progenitor cells was observed in both cyclic (CN) and severe congenital neutropenia (SCN). Short and long-term cultur...

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Identifiers

PMID: 12468929
DOI: 10.1097/00043426-200212000-00025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12468929-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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