Article
Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans.
Genes and immunity - 1 Jun 2003
Duggal P, An P, Beaty T H, Strathdee S A, Farzadegan H, Markham R B, Johnson L, O'Brien S J, Vlahov D, Winkler C A
Abstract excerpt
CXCR6 is a chemokine receptor and the primary coreceptor in SIV infection. A single nucleotide polymorphism 1469G-->A, results in a nonconservative change in codon 3 (CXCR6-E3K) of the N-terminus of the coreceptor. To investigate the relation between the chemokine receptor CXCR6 genotype and progression to Pneumocystis carinii pneumonia (PCP) and from PCP to death, we clinically assessed and genotyped 805...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.