Article
Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population.
Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2005
Petersen Desiree C, Glashoff Richard H, Shrestha Sadeep, Bergeron Julie, Laten Annette, Gold Bert, van Rensburg Estrelita Janse, Dean Michael, Hayes Vanessa M
Abstract excerpt
CXC chemokine ligand 12 (CXCL12), or stromal cell-derived factor 1 (SDF1), is the only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in some studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS...
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