Article
Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study.
AIDS (London, England) - 1 Dec 2000
McDermott D H, Beecroft M J, Kleeberger C A, Al-Sharif F M, Ollier W E, Zimmerman P A, Boatin B A, Leitman S F, Detels R, Hajeer A H, Murphy P M
Abstract excerpt
OBJECTIVE: To examine whether polymorphism in the RANTES gene is associated with HIV disease outcome. DESIGN: RANTES, a ligand of the major HIV co-receptor, CCR5, is known to block HIV-CCR5 interactions. Recently, two single nucleotide polymorphisms in the RANTES gene promoter region, designated -403G/A and -28C/G, have been described. Both polymorphisms can affect in-vitro promoter activity, and the RANTES...
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