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Article

The BLNK adaptor protein has a nonredundant role in human B-cell differentiation.

The Journal of allergy and clinical immunology - 1 Jul 2014

Lagresle-Peyrou Chantal, Millili Michèle, Luce Sonia, Boned Annie, Sadek Hanem, Rouiller Julien, Frange Pierre, Cros Guilhem, Cavazzana Marina, André-Schmutz Isabelle, Schiff Claudine

Abstract excerpt

BACKGROUND: Expression of the pre-B-cell receptor (pre-BCR) by pre-BII cells constitutes a crucial checkpoint in B-cell differentiation. Mutations that affect the pre-B-cell receptor result in early B-cell differentiation blockades that lead to primary B-cell immunodeficiencies. BLNK adaptor protein has a key role in the pre-B-cell receptor signaling cascade, as illustrated by the abnormal B-cell development in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24582315
DOI: 10.1016/j.jaci.2013.12.1083

Genes

BLNK
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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